The causal relationship between leisure screen time and irritable bowel syndrome.
By Hugo Francisco de SouzaAug 18 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Scientific Reports journal, researchers employed Mendelian randomization analyses of large-scale genome-wide association studies to investigate the causal relationship between leisure screen time and irritable bowel syndrome .
The pathology and etiology of the disease are multifaceted, with genetics, infection, intestinal motility, and chronic inflammation assumed to contribute to IBS. Large cohort observational studies and meta-analyses have revealed that excess LST, one of the most detrimental sedentary behaviors, is independently responsible for CVD and cancers of the lung, breast, colon, and prostate. Alarmingly, every additional two hours of television watching has been reported to increase colorectal cancer risk by 1.07%.
About the study The present study employed Mendelian Randomization approaches to investigate LST and IBS risk associations. Mendelian randomization is a form of instrumental variable analysis that uses single nucleotide polymorphism associations from genome-wide association studies as instruments to study and uncover causal relationships between complex traits.
The dataset comprised 19.1–22.5 million SNPs per trait, with individual-recorded variables including sex, ancestry, and type of sedentary LST activity . Confounding characteristics, including body fat mass, adiposity, body mass index , body fat percentage, and waist-to-hip ratio, were removed before rerunning the MR analysis to evaluate the impacts of these variables on IBS association or strength.
Previous studies have reported that adiposity and BMI are correlated with LST, with the former potentially mediating the causation or symptom strength of the latter. This would result in confounding effects, so SNPs associated with BMI were removed, resulting in 47 remaining SNPs.
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