Trust your gut? Your doctor likely will, too. Probiotics engineered to sense and report signs of bowel inflammation could deliver firsthand knowledge of your system's inner workings—provided they are not killed or dispersed in the process.
, but also to monitor disease progression, assess treatment response and help provide care tailored to individual patients' unique gut microbiome.
"With our system, patients could theoretically receive a prescription for the capsules and simply drop off a stool sample after ingestion, eliminating the need for repeated colonoscopies or biopsies," said Samira Aghlara-Fotovat, a bioengineering graduate student in the Veiseh lab."Monitoringover time or keeping track of how a patient is responding to a given therapy could be much more accessible using a platform like this.
"If, in the future, we encapsulate a diverse range of biosensor strains, we could get an idea about a specific person's inflammatory profile and then use that information to develop a more personalized diagnosis and treatment," Aghlara-Fotovat said. The engineered strain produces a fluorescent green protein in response to thiosulfate—a compound associated with gut inflammation ⎯ making it possible to assess colon inflammation by measuring bacterial fluorescence after passage through the animal GI tract.
"As we worked on developing our platform, we encapsulated bacteria countless times, optimizing each step of the process along the way. There were so many aspects that needed to be characterized well in order to make a clinically translatable product," Aghlara-Fotovat said.
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