High levels of niacin, an essential B vitamin, may raise the risk of heart disease by triggering inflammation and damaging blood vessels, according to new…
Excess amounts of vitamin B3 — which is found in meat, fish, nuts, and fortified cereals and breads — may trigger inflammation and damage blood vessels., the report published Monday in Nature Medicine, revealed a previously unknown risk from excessive amounts of the vitamin, which is found in many foods, including meat, fish, nuts, and fortified cereals and breads., said the study’s senior author, Dr.
That finding led to two additional “validation” studies, which included data from a total of 3,163 adults who either had heart disease or were suspected of having it. The two investigations, one in the U.S. and one in Europe, showed that the niacin breakdown product, 4PY, predicted participants’ future risk of heart attack, stroke and death.
The newly detected pathway to heart disease might lead to the discovery of a medication that could reduce blood vessel inflammation and decrease the likelihood of major cardiovascular events, he added. The new information could influence dietary recommendations for niacin, said Rosenson, who was not involved with the Cleveland Clinic research.
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