Maternal obesity can affect fetal development upvehu CommsBio
These authors jointly supervised this work: Marie-France Hivert, Jose Ramon Bilbao.
Deakin University, IMPACT – the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, AustraliaDepartment of Public Health Sciences and the MIND Institute, University of California Davis School of Medicine, Davis, CA, USAMartine Vrijheid & Mariona BustamanteDepartment of Biochemistry and Functional Genomics, Universite de Sherbrooke, Sherbrooke, QC, CanadaDepartment of Laboratory Medicine, CIUSSS du Saguenay–Lac-St-Jean – Hôpital Universitaire...
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DIMPLE: deep insertion, deletion, and missense mutation libraries for exploring protein variation in evolution, disease, and biology - Genome BiologyInsertions and deletions (indels) enable evolution and cause disease. Due to technical challenges, indels are left out of most mutational scans, limiting our understanding of them in disease, biology, and evolution. We develop a low cost and bias method, DIMPLE, for systematically generating deletions, insertions, and missense mutations in genes, which we test on a range of targets, including Kir2.1. We use DIMPLE to study how indels impact potassium channel structure, disease, and evolution. We find deletions are most disruptive overall, beta sheets are most sensitive to indels, and flexible loops are sensitive to deletions yet tolerate insertions.
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CLIC and membrane wound repair pathways enable pandemic norovirus entry and infection - Nature CommunicationsCulture methods for studying human norovirus infection have been recently established. Here, Ayyar and colleagues use human intestinal enteroids to dissect viral entry mechanisms and show that CLIC-mediated endocytosis and wound repair pathways are exploited by pandemic norovirus.
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Breakthrough in California murder case after 43 years as DNA from 1994 finally testedPatricia Carnahan's body was found at a campground at Lake Tahoe on 28 September 1979. Her identity was not discovered until 2015 when the case was re-examined. Police have only now arrested a murder suspect after testing DNA collected in 1994 for an alleged sexual assault.
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Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer | Journal of Cell Biology | Rockefeller University PressPancreatic ductal adenocarcinoma (PDAC) is a deadly disease whose molecular etiology remains mostly enigmatic. By discovering an antagonistic relationship betwe
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