Weight loss in obese subjects could reverse type 2 diabetes progression UF Diabetes Weightloss Obesity DiabetesReversal Type2Diabetes Progression
By Dr. Liji Thomas, MDFeb 28 2023Reviewed by Aimee Molineux Type 2 diabetes mellitus is caused by the dysfunction of beta cells in the endocrine pancreas, coupled with insulin resistance. This could be induced by environmental or epigenetic factors.
The model reported in the current paper, which appears in PLOS Computational Biology, analyzed diabetes progression regarding multiple diabetogenic factors, including those related to the individual’s obesity threshold for increased diabetes risk, those relating ethnicity to a tolerance of factors promoting weight gain above the obesity threshold, as well as the effect of bariatric surgery on T2DM risk.
These long-term trends showed a close correlation to actual longitudinal data when fitted to a specific population, in this case, Pima Indian individuals. This group was chosen because of the long follow-up data available on the long-term changes and direction of glucose concentrations. The simulation also showed that when the same individual was exposed to an environment with only a mild obesogenic risk, the rate of progression and severity of disease were markedly reduced. Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy The results confirmed what the scientists suspected. With proper control of obesity, T2DM could be reversed or postponed, or at least its severity reduced.
A concept called personal fat threshold is being used to personalize diet plans for diabetic patients, using individualized susceptibilities to excessive lipids of specific types, as well as the amount of fat stored in the pancreas and liver.
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Childhood adiposity and novel subtypes of adult-onset diabetes: a Mendelian randomisation and genome-wide genetic correlation study - DiabetologiaAims/hypothesis We investigated whether the impacts of childhood adiposity on adult-onset diabetes differ across proposed diabetes subtypes using a Mendelian randomisation (MR) design. Methods We performed MR analysis using data from European genome-wide association studies of childhood adiposity, latent autoimmune diabetes in adults (LADA, proxy for severe autoimmune diabetes), severe insulin-deficient diabetes (SIDD), severe insulin-resistant diabetes (SIRD), mild obesity-related diabetes (MOD) and mild age-related diabetes (MARD). Results Higher levels of childhood adiposity had positive genetically predicted effects on LADA (OR 1.62, 95% CI 1.05, 2.52), SIDD (OR 2.11, 95% CI 1.18, 3.80), SIRD (OR 2.76, 95% CI 1.60, 4.75) and MOD (OR 7.30, 95% CI 4.17, 12.78), but not MARD (OR 1.06, 95% CI 0.70, 1.60). Conclusions/interpretation Childhood adiposity is a risk factor not only for adult-onset diabetes primarily characterised by obesity or insulin resistance, but also for subtypes primarily characterised by insulin deficiency or autoimmunity. These findings emphasise the importance of preventing childhood obesity. Graphical abstract
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