A combination of two therapies shows promise for treatment-resistant cancers. The immune system has evolved to safeguard the body from an incredibly diverse range of potential threats. Among these are bacterial diseases, including plague, diphtheria, cholera, and Lyme disease, and viral contagions
The illustration shows a cancer cell surrounded by immune T-cells augmented with an oncolytic virus. A new study describes how a combination of immunotherapy and virotherapy, using myxoma virus, provides new hope for patients with treatment-resistant cancers. Credit: Graphic by Jason DreesThe immune system has evolved to safeguard the body from an incredibly diverse range of potential threats.
Grant McFadden directs the Biodesign Center for Immunotherapy, Vaccines and Virotherapy. He is also a center director and professor at the School of Life Sciences. Credit: The Biodesign Institute at Arizona State University Known as autosis, this form of cell destruction may be especially useful against solid tumors that have proven treatment-resistant to various forms of cancer therapy, including immunotherapy alone.
Through a range of evasive strategies, cancer cells can further short-circuit immune efforts to hunt and destroy them. Scientists hope to help the immune system to overcome cancer’s notorious tactics of disguise, by developing new experimental techniques belonging to a category known as adoptive cell therapy, or ACT.
During myxoma-mediated autosis, cancerous cells in the proximity of those targeted by the therapy are also destroyed in a process known as bystander killing. This effect can considerably enhance the dual therapy’s aggressive eradication of cancer cells, even in notoriously hard-to-treat solid tumors.
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