Diabetes: When circadian lipid rhythms go wrong UNIGEnews PLOSBiology
Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editingThoracic and Endocrine Surgery Division, Department of Surgery, University Hospital of Geneva,
Geneva, Switzerland, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland, Diabetes Center, Faculty of Medicine, University of Geneva, Geneva, Switzerland, Institute of Genetics and Genomics in Geneva , Geneva, Switzerland
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FIRST ALERT: Close to an Inch of Rain Possible for Some Areas Through TuesdaySummer was snuffed out in a matter of minutes Sunday night as a “backdoor” cold front slipped in from Maine. We use this term to describe this particular type of front that comes from a rather odd direction – the northeast. Typically, our weather comes in from the west (via Albany and Springfield). These fronts are common in the spring…
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SARS-CoV-2 infection, vaccination, and antibody response trajectories in adults: a cohort study in Catalonia - BMC MedicineBackground Heterogeneity of the population in relation to infection, COVID-19 vaccination, and host characteristics is likely reflected in the underlying SARS-CoV-2 antibody responses. Methods We measured IgM, IgA, and IgG levels against SARS-CoV-2 spike and nucleocapsid antigens in 1076 adults of a cohort study in Catalonia between June and November 2020 and a second time between May and July 2021. Questionnaire data and electronic health records on vaccination and COVID-19 testing were available in both periods. Data on several lifestyle, health-related, and sociodemographic characteristics were also available. Results Antibody seroreversion occurred in 35.8% of the 64 participants non-vaccinated and infected almost a year ago and was related to asymptomatic infection, age above 60 years, and smoking. Moreover, the analysis on kinetics revealed that among all responses, IgG RBD, IgA RBD, and IgG S2 decreased less within 1 year after infection. Among vaccinated, 2.1% did not present antibodies at the time of testing and approximately 1% had breakthrough infections post-vaccination. In the post-vaccination era, IgM responses and those against nucleoprotein were much less prevalent. In previously infected individuals, vaccination boosted the immune response and there was a slight but statistically significant increase in responses after a 2nd compared to the 1st dose. Infected vaccinated participants had superior antibody levels across time compared to naïve-vaccinated people. mRNA vaccines and, particularly the Spikevax, induced higher antibodies after 1st and 2nd doses compared to Vaxzevria or Janssen COVID-19 vaccines. In multivariable regression analyses, antibody responses after vaccination were predicted by the type of vaccine, infection age, sex, smoking, and mental and cardiovascular diseases. Conclusions Our data support that infected people would benefit from vaccination. Results also indicate that hybrid immunity results in superior antibody responses and
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Mohammed Bin Salman: Saudi Prince's controversial invitation to the Queen's funeralSaudi prince's invitation to the Queen's funeral is 'a stain on the memory of Queen Elizabeth II' say human rights campaigners
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Is there any impact of COVID-19 vaccines on the fertility of men and women of reproductive age?Is there any impact of COVID-19 vaccines on the fertility of men and women of reproductive age? Unicatt COVID19 coronavirus covid ferility SARSCoV2 reproductivehealth
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