A study published in BMCInfectDis finds that vasopressin initiation when low-dose norepinephrine is used in adults with septic shock was associated with an improvement in 28-day mortality. Further trials are needed to confirm this conclusion.
]. Therefore, based on the NE dose at the time of vasopressin initiation, patients were classified into two groups: the low doses of NE group and the high doses of NE group .The primary end-point was 28‐day mortality after diagnosis of septic shock.
The Sepsis-3 criteria for sepsis were extracted as suspected infection with associated organ dysfunction []. The onset time of septic shock was defined as the first time of NE initiation and a MAP of < 65 mm Hg was recorded. Fluid bolus volume was defined as any fluid bolus given from 6 h prior to shock onset through the time of vasopressin initiation.
]. When the patients were alive, the mechanical ventilation-free days and CRRT-free days were calculated as the number of days out of 28 days. If patients died within 28 days, the free days were defined zero.To reduce the influence of potential confounders between the two groups, propensity score matching analysis was conducted with the 1:1 optimal matching method and a caliper width of 0.02 by the “MatchIt” package in R software.
Another PSM analysis was conducted based on the gradient boosted model with the “twang” package for the sensitivity analysis. The estimated propensity scores were calculated using a regression tree with all covariates in GBM. Subsequently, we built an inverse probabilities weighting model for generating a weighted cohort with the estimated propensity scores as weights [].
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