The longer the bootcamp, the better the antibodies: Scientists test new vaccine strategy to help the body target HIV ljiresearch nature
The new study shines a light on the importance of stretching out the period where B cells can evolve in the germinal centers.
The researchers then tracked immune responses by examining monkey lymph nodes. The team also monitored B cell development in individual germinal centers. Their work revealed that the germinal centers stayed active and B cells continued to evolve for six months after the initial seven-shot series. As Sutton points out, the study was set to end after six months, but the germinal centers may have lasted even longer if the research had gone on.
The slow delivery, escalating dose strategy had paid off. The large dose of antigen had likely given the immune system enough of a"taste" of the virus that the germinal centers were ready to stay open and the B cells were prompted to evolve for as long as possible to address the perceived threat.When it comes to vaccinating against HIV, it appears that timing really is key to long-term protection. Giving vaccine boosters too early may interrupt an already effective process.
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