Rhombic lip implicated in origins of high-risk medulloblastoma nature
Transcriptional atlas of the human fetal cerebellum. Schematic summary of the molecular datasets used to interconnect mouse and human cerebellar profiles with MB. Single-cell and bulk sample counts for each data source are indicated. UMAP plots showing published cell-type annotation and predicted cell-cycle phase of the human fetal cerebellar atlas. Credit:Scientists at St. Jude Children's Research Hospital have discovered which cells give rise to certain high-risk groups of medulloblastoma.
"There has existed this ambiguity and overlap between group 3 and group 4 that made it challenging to resolve their origins," said corresponding author Paul Northcott, Ph.D., St. Jude Department of Developmental Neurobiology."We've had evidence that these groups had some kind of common ancestry that then likely diverged depending on the genetic events driving those tumors, but we couldn't say that definitively until now.
Northcott then collaborated with the current study's co-senior author Kathleen Millen, Ph.D., at Seattle Children's. Millen and her team created the first atlas of human cerebellar development. Armed with the human atlas, Northcott and his team were able to look for the transcriptomic signatures of the different medulloblastoma subgroups in the context of the same species.
The researchers matched these distinct populations of cells from the rhombic lip with group 3 and group 4 medulloblastomas. Group 3 cells are more primitive whereas group 4 cells are further along in their development .
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