Improving human quality of life with drug treatments is a complicated issue. Drug certification, including drug safety and reliability, entails a long series of tests and government approvals before the drug is available for anyone to use.
Virginia TechJul 22 2024
Therapeutics fail in clinical trials because they can't cross the blood-brain barrier. The reality is that the devices that have been created in a lab don't work and they allow too much to pass through. This gives false information that molecules can get through, and when you get into a clinical trial, the drugs fail because the human brain conditions haven't been properly duplicated.
Synthetic devices and living cells Schultz and Davalos have already collaborated on new methods for 3D printing medical devices using materials that had been problematic in drug trials up to that point. In phase one of this project, they devised a way to 3D-print polydimethylsiloxane , a silicone polymer that could be used to mimic the blood-brain barrier. That project received $173,000 from the NIH.
After seeing success in the first phase, Schultz and Davalos saw possibilities in expanding the project. Amrinder Nain had expertise and tools ready for the task and had previously collaborated with Davalos. "What's really nice about using Amrinder 's fiber network is that it's so thin, you can have cells on either side that can communicate," said Davalos. "This creates tight junctions between cells to prevent therapeutics from passing through."
Blood Brain Clinical Trial Drugs Hospital Medical School Membrane Microfluidics Technology Therapeutics
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