Study characterizes immunological signature of SARS-CoV-2 infection in children researchsquare LaStatale SARSCoV2 COVID19 ImmunologicalSignature
By Dr. Sanchari Sinha Dutta, Ph.D.Sep 26 2022Reviewed by Aimee Molineux A recent study conducted by a team of Italian scientists has demonstrated that the clinical severity of coronavirus disease 2019 in children depends on the dynamics of immune response induced by severe acute respiratory syndrome coronavirus 2 infection.
The reason behind the observed variation in clinical severity between children and adults is not fully known. However, it has been hypothesized that the pattern of social interactions, viral load, and age-related dynamics of immune response make children less susceptible to SARS-CoV-2 infection. The patients were categorized based on clinical severity and age. Moderate and severe infections were found in 56% and 44% of patients. The average duration of hospital stay was 12 days, with only one child admitted to the intensive care unit .
In addition to clinical severity, age-related differences in antibody response were assessed in hospitalized children. Based on age, they were categorized as infants, children, and adolescents. The comparison of inflammatory and antibody responses revealed a negative correlation between antibody and cytokine/chemokine levels in infants and children with severe infection and cardiovascular involvement. In particular, anti-SARS-CoV-2 binding antibodies showed a negative correlation with interleukin 2 .
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