Systemic inflammation triggered by SARS-CoV-2 found to cause human testicular injury biorxivpreprint uhmanoa SARSCoV2 COVID19 MensHealth Inflammation
By Neha MathurSep 26 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, a team of researchers demonstrated that the testicular injury in humans is not due to direct severe acute respiratory syndrome coronavirus 2 infection but more likely is an indirect effect of exposure to systemic inflammation or SARS-CoV-2 antigens.
Abundant ACE2 receptors in resident testicular cells might be responsible for testicular injury during SARS-CoV-2 infection. In testis, ACE2 regulates testosterone production and interstitial fluid volume via modulating the conversion of Angiotensin 2 to Angiotensin 1. Other causes of testicular injury could be direct virus infection of resident cells or exposure to systemic inflammatory infection mediators or virus antigens.
First, the team infected well differentiated 2D cultures of human airway epithelial cells grown on transwell inserts at a multiplicity of infection equals one and measured infectious virions on the apical and basal sides of the inserts. Study findings The researchers detected SARS-CoV-2 RNA in the range of log 2 to 3 genome copies in all cell models, but the virus copies did not increase between 24 and 96 hpi. SARS-CoV-2 infection of SC and LC at a higher MOI of 10 also did not trigger SARS-CoV-2 virions release in the HAE supernatant over 96 hours. Likewise, the immunofluorescence assay could not detect the SARS-CoV-2 spike protein in infected SC and LC.
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