Nature research paper: Reconstruction and deconstruction of human somitogenesis in vitro
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.The vertebrate body displays a segmental organization which is most conspicuous in the periodic organization of the vertebral column and peripheral nerves.
Here we introduce novel tridimensional culture systems of human pluripotent stem cells , called Somitoids and Segmentoids, which recapitulate the formation of somite-like structures with antero-posterior identity. We identify a key function of the segmentation clock in converting temporal rhythmicity into the spatial regularity of anterior and posterior somitic compartments.
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