A single oral administration of an LSD-based medicine provided rapid and durable improvement in moderate to severe generalized anxiety disorder (GAD) in a phase 2B study.
A single oral administration of MM120 , an investigational lysergic acid diethylamide –based medicine being developed by Mind Medicine Inc , provided rapid and durable improvement inAt 12 weeks, 65% of patients treated with MM120 100 µg had a clinical response, defined as at least a 50% reduction in total scores on the Hamilton Anxiety Rating scale , and 48% achieved remission, defined as HAM-A total score ≤ 7.
The phase 2B, multicenter, double-blind, placebo-controlled, dose-optimization study of MM120 enrolled 198 adults with moderate to severe GAD . They were randomly allocated to receive a single dose of 25 µg, 50 µg, 100 µg, or 200 µg of MM120 or placebo. On average, Clinical Global Impressions – Severity scores improved from 4.8 to 2.2 in the 100 µg–dose group. This represents a two-category shift from"markedly ill"to"borderline ill"at week 12 , visual hallucination , mydriasis , altered state of consciousness , anxiety , blood pressure increase , and abnormal thinking .
Anxiety Generalized Anxiety Disorder GAD - Generalized Anxiety Disorder Generalised Anxiety Disorder GAD - Generalised Anxiety Disorder Depression Anxiolytic Hallucination Healthcare And Medical Technology Health And Medical Tech Health And Med Tech Health And Medical Technology Healthcare Technology Medical Technology Mental Illness Mental Disorder
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