Notre Dame vs. Louisville predictions: Odds, picks, predictions, best bets and promotions for CFB Saturday

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Notre Dame vs. Louisville predictions: Odds, picks, predictions, best bets and promotions for CFB Saturday
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The Red River Rivalry between No. 12 Oklahoma and No. 3 Texas highlights this week’s college slate

If you make a purchase after clicking on links within this article, Lee Enterprises may earn affiliate commissions. The news and editorial departments had no role in the creation or display of this content. How good is 5-0 Louisville? No. 10 Notre Dame will provide a physical, in-your-face measuring stick.

Notre Dame vs. Louisville odds, preview and prediction: Louisville and Notre Dame have one common opponent, North Carolina State. Louisville and Notre Dame beat the Wolfpack on the road: Louisville by 13-10; Notre Dame by 45-24. Notre Dame quarterback Sam Hartman has the program record of 145 pass attempts without an interception. His passing prowess and Audric Estime’s running make the Irish offense click.

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