Cancerous bladder cells with a missing Y chromosome are better prepared to evade our immune system, according to a new study using mice and conducted by researchers from Cedars-Sinai Medical Center and The Ohio State University in the US.
A scan through the proteins produced by the mouse cancer cells and comparing critical immune cells present in the two different tumor types helped further fill in the picture, suggesting cancer-fightingSifting through databases of proteins active in human bladder cancers supported the mouse models' findings, affirming that the presence of a Y chromosome in bladder cells produces important proteins that help the immune system's onslaught against the growing tumor.
Not only does this give medical specialists something to look for in determining the aggression of bladder cancers, but further experimentation also showed Y negative tumors respond well to a type of cancer treatment known as anIf you're inspired to give your Y chromosomes a big, hearty hug and tell them you'll never let them go, you might want to hold off.
An analysis of a known mutation found it regulates a gene on the Y chromosome that's primarily responsible for giving tumors a leg-up in migrating around the mouse body. That Y chromosome gene happens to be KDM5D, one of the specific genes identified as protective in bladder cancer. Depending on the tissue type, this diminutive 'pamphlet' of a chromosome could be a cancer-fighting weapon or a how-to manual for a tumor to set sail and invade new organs. It just depends on which disease you prefer to be at the most risk of.out as an evolutionary fashion, it's hard to know whether we should be celebrating or lamenting.
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