Taking piroxicam, an anti-inflammatory medication commonly used for arthritis pain, at the same time as the levonorgestrel emergency contraceptive pill after unprotected sex prevents significantly more pregnancies compared to taking levonorgestrel alone, according to a randomized controlled trial published in The Lancet.
method in most countries, with the levonorgestrel pill available in more countries than the ulipristal acetate pill. Both contraceptives work by preventing or delaying ovulation and neither are effective post-ovulation.
First author of the study Dr. Raymond Li from The University of Hong Kong added,"Our study is the first to suggest that a readily available and safe medication taken at the same time as the levonorgestrel pill can prevent more pregnancies than levonorgestrel alone. We hope these results will lead to further research and ultimately changes in clinical guidelines to enable women around the world to access more effective emergency contraception.
Of the 836 women followed up, there was one pregnancy among the 418 women who took piroxicam and levonorgestrel and seven pregnancies among the 418 women who had the placebo and levonorgestrel. The percentage of expected pregnancies without contraception was estimated at 4.5% in both groups. Therefore, the percentage of pregnancies prevented following piroxicam- levonorgestrel co-treatment was 95% , compared with 63% in those who took levonorgestrel and placebo.
"Therefore, we speculate that piroxicam may provide a contraceptive effect both pre-ovulation and post-ovulation , however our trial did not investigate piroxicam's mechanism of action and further studies are required to confirm this."
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