From a forgotten drug to a much cheaper cancer test and using artificial intelligence to detect cancer, find out what researchers in Singapore have contributed to the improvement of cancer detection methods and treatment therapies.
Cancer remains the number one cause of death in Singapore. What is also irrefutable is that the number of new cases continues to rise through the decades.
One factor contributing to the improvement could be the development of more targeted medicines. The one-size-fits-all approach has been giving way to precision medicine that “targets the right treatment to the right patient at the right time”, said Dr Richard Quek, a senior consultant in medical oncology at Parkway Cancer Centre.
Furthermore, the new test uses blood samples instead of tissue samples taken from biopsies, which are more invasive to the patient. He is leading the team consisting of researchers from the NUS Department of Biomedical Engineering under the College of Design and Engineering as well as the NUS Institute for Health Innovation & Technology.
Type A abnormalities involve proteins that sustain the multiplication of cancer cells, while type B ones are characterised by an abnormal signalling pathway that promotes the emergence of cancer cells. Together, the two mechanisms support the proliferation of malignant T-ALL cells. PIK-75 was found to be able to block the protein as well as the signalling pathway.
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