Health Canada is reviewing the safety of domperidone reports that some mothers in Canada and the U.S. have had serious psychiatric symptoms.
Health Canada is reviewing the safety of domperidone amid reports that some breastfeeding mothers in Canada and the U.S. have had serious psychiatric symptoms when they tried to stop taking the drug. A woman nurses her son at a nurse-in, Wednesday, January 19, 2011 in Montreal.
“The safety review, which started in December 2022, was prompted by domestic and foreign case reports of withdrawal symptoms after stopping or reducing the dose of domperidone used to stimulate lactation,” Health Canada said in a statement on Tuesday.When used to help with breastfeeding, domperidone is routinely prescribed in higher amounts than the 30 mg a day approved by Health Canada for gastrointestinal symptoms.
Although he’s not aware of any clinical trials examining possible psychiatric effects of domperidone among breastfeeding mothers, it’s important to pay attention to the “signal” these case studies are sending, said Dr. Jonathan Zipursky, a specialist in clinical pharmacology and toxicology at Sunnybrook Health Sciences Centre in Toronto.
“Should new safety risks be confirmed, Health Canada will take appropriate action and continue to keep Canadians informed,” it said.
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