.NIH-supported researchers found that a person’s DNA could be the key to diagnosing endometriosis, and to customizing treatment. Learn more: EndometriosisAwarenessMonth
Currently, a diagnosis of endometriosis can only be made using a surgical procedure.In endometriosis, tissue similar to that in the lining of the uterus grows in other places in the body. It may grow in the ovaries, fallopian tubes, bowels, or bladder. Endometriosis affects 5 to 10% of women in the United States. The main symptoms are pain, especially during menstrual periods, and infertility.
To better understand how cells in the uterus respond to these two hormones, a research team led by Drs. Sahar Houshdaran and Linda C. Giudice at the University of California, San Francisco examined endometrial stromal fibroblast cells, which regulate cells in the lining of the uterus. They compared cells from women with stage I and stage IV endometriosis as well as those without the condition.
The cells also showed distinct DNA methylation and gene expression patterns for each of the hormone conditions. Cells from women with endometriosis showed abnormal genetic responses to both progesterone and estrogen.
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