Researchers at Scripps Research discovered that apremilast (Otezla®) can reduce alcohol consumption by over 50% in individuals with severe alcohol use disorder. A clinical trial conducted by Scripps Research Institute has revealed that apremilast, an FDA-approved medication for the treatment of p
and other institutions found that in mice, apremilast increases activity in a region of the brain known to play a role in AUD.“We’re incredibly excited to have found a drug that has such a large effect size on alcohol consumption, and with such good tolerability and safety at the same time,” says co-senior author Barbara Mason, Ph.D., the Pearson Family Chair and Director of the Pearson Center for Alcohol and Addiction Research at Scripps Research.
Mason is the director of the Translational Opportunities group for the Integrative Neuroscience Initiative on Alcoholism-NeuroImmune , a multidisciplinary, collaborative consortium funded by the National Institute on Alcohol Abuse and Alcoholism to study the underlying biology of alcohol use disorder. In her role with INIA-NeuroImmune, Mason reviews research conducted by basic scientists in the consortium and then identifies the most promising drug candidates for clinical trials.
Mason launched a phase 2 trial, carried out entirely at the Pearson Center for Alcoholism and Addiction Research at Scripps Research, to study apremilast in humans. Among available PDE4 inhibitor medications, Mason chose apremilast because it had fewer of the gastrointestinal side effects associated with earlier PDE4 inhibitors such as rolipram or ibudilast. The trial enrolled 51 paid adult volunteers with severe AUD, none of whom were actively trying to consume less alcohol.
“In this study, we saw that apremilast worked in mice. It worked in different labs, and it worked in people. This is incredibly promising for treatment of addiction in general,” says co-senior author Angela Ozburn, Ph.D., associate professor of behavioral neuroscience in the OHSU School of Medicine and a research biologist with the Portland VA Health Care System.
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