Commentary: Nobel prize for mRNA vaccine shows power of perseverance

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Commentary: Nobel prize for mRNA vaccine shows power of perseverance
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The COVID-19 shots that seemed to appear overnight were built on decades of work by Katalin Kariko and Drew Weissman, says Bloomberg Opinion columnist Lisa Jarvis.

US physician-scientist Drew Weissman along with his long-time collaborator Katalin Kariko of Hungary won the 2023 Nobel Medicine Prize for mRNA vaccine research. It’s hard to imagine a more deserving Nobel Prize than one for an achievement credited with saving millions of lives. And we might never have gotten here if scientists like Kariko hadn’t persisted in the face of doubt.

Kariko and Weissman are credited with cracking the last item on that list. By swapping out a basic building block of mRNA called uridine for a related molecule called pseudouridine, strands of mRNA could get their message to cells without triggering an immune attack. Kariko’s struggle to convince the world of mRNA’s value ultimately pushed her out of academia and to BioNTech, which she joined in 2013. By then, investors had started to come around to the idea that mRNA could be useful. But only a handful of companies were pursuing the idea.

Yet for mRNA’s full potential to be realised - and Kariko’s dream of turning it into a therapeutic - the field will need another dose of her brand of intense determination. While undeniably world-changing, vaccines are also the low-hanging fruit of the mRNA world. To work, they only need to coax cells into making a fleeting amount of protein - enough to train the immune system so that it can eventually spot the real virus.

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