Researchers developed a three-dimensional (3D) biologically printed in vitro model of the breast cancer tumor microenvironment.
By Pooja Toshniwal PahariaAug 28 2023Reviewed by Lily Ramsey, LLM In a recent study published in Scientific Reports, researchers developed a three-dimensional biologically printed in vitro model of the breast cancer tumor microenvironment consisting of simultaneously cultured cells dispersed in hydrogels with a controlled design to assess tumor heterogeneity.
About the study In the present study, researchers developed a platform using 3D biological printing to model the phenotypic heterogeneity resulting from different cell localizations in a tumor. To induce cellular heterogeneity, the team mixed the cells randomly or arranged them in consecutive layers. A progressive chemical gradient was created to analyze cell migration in the direction of the epithelial growth factor chemoattractant in MCF10A cell presence in varied ratios.
A tree-like gradient generator was created that could be combined with the tumor-on-chip model's three-dimensional biological printing. The model had a length of 45 mm and a width of 21 mm. The microfluidic gradient generator was built using standard lithography techniques. The team observed excellent cell dispersion inside the construct with an absorbance value of 0.9 immediately after printing.
The cell population and cell ratio were different near the margins of the 2D chamber compared to the centre of the chamber, but the tumor cells were placed uniformly in the 3D biologically printed structure.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Scottish Government's wildlife reforms go 'above and beyond', says pest controllerTHE Scottish Government’s wildlife management reforms go “above and beyond” expectations, according to a pest controller who consulted on the…
Read more »
Explained: Summer transfer deadline in PL, Saudi and beyondAll you need to know about transfer deadline day in the Premier League, across Europe and beyond
Read more »
Scientists hope radiotherapy breakthroughs will transform cancer treatmentResearchers have been working to improve a treatment called proton beam radiotherapy.
Read more »
Scientists hope radiotherapy breakthroughs will transform cancer treatmentResearchers have been working to improve a treatment called proton beam radiotherapy.
Read more »
Time-restricted feeding reverses Alzheimer's symptoms in mice, offers new hope for accessible treatmentResearchers explore the therapeutic potential of circadian-modulating interventions to treat Alzheimer’s disease.
Read more »
Solving for Y: Research team completes long-anticipated genome sequencing of Y chromosomeTwenty years ago, when researchers from the Human Genome Project announced that they had completed the first-ever sequence of an entire set of human DNA, the discovery was heralded as comparable to 'splitting the atom or going to the moon.' The announcement forever transformed the fields of genomics, biology, and medicine, allowing researchers to investigate more complex questions and seek more complicated answers related to the human body and how to treat disease.
Read more »