Could antidepressants hold the key to treating long COVID?
Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. University of Pennsylvania researchers have uncovered a link between long COVID and levels of serotonin in the body that may offer a new explanation for the condition. The study even points to a possible treatment.
"Long COVID can have manifestations not only in the brain but in many different parts of the body, so it's possible that serotonin reductions are involved in many different aspects of the disease," said Thaiss., found lower serotonin levels in long COVID patients in comparison with patients who were diagnosed with acute COVID-19 but who fully recovered.
Persistent circulating virus is one of the drivers of low serotonin levels, said study author Michael Peluso, MD, an assistant research professor of infectious medicine at the University of California, San Francisco, School of Medicine. This points to the need to reduce viral load using antiviral medications like nirmatrelvir/, which is approved by the US Food and Drug Administration for the treatment of COVID-19, and VV116, which has not yet been approved for use against COVID.
David F. Putrino, PhD, who runs the long COVID clinic at Mount Sinai Health System in New York City, said the research is helping"to paint a biological picture" that's in line with other research on the mechanisms that cause long COVID symptoms. Traditionally, SSRIs are used clinically for increasing the levels of serotonin in the brain, not the body.
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