Why are there more women with Alzheimer's than men?
Eliminating excess tau begins with the addition of a chemical tag called ubiquitin to the tau protein, according to the study. A dysfunction of this process can lead to abnormal accumulation of tau.
Researchers looked for increased activity of the enzymatic systems that either added or removed the ubiquitin tag. That led to the finding that female mice and humans both naturally expressed higher levels of USP11 than men. They also found that USP11 levels correlate strongly with brain tau pathology in females, but not in males.
When researchers genetically eliminated USP11 in a mouse model, the females were protected from tau pathology and thinking impairment. Males were also protected against tau pathology in the brain, but not as much as females. While this suggests that excessive activity of the USP11 enzyme in females drives those increases in tau pathology, mouse models may not fully show what will happen in humans.Copyright © 2022 HealthDay. All rights reserved.
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