Scientists used data from over 300 human fecal microbiota transplants to gain an ecological understanding of what happens when two gut microbiomes clash together. Fecal microbiota transplantation (FMT) is the transfer of lower intestinal fluids and microbes from one individual to another. It is s
Fecal Microbiota Transplantation as the confluence of a donor’s and recipient’s gut ecosystems. The various “pipes” in the image represent human gastrointestinal tract and the bacteria within represent the recipient’s and donor’s microbial strain populations that are pitched against each other. Credit: Aleksandra Krolik / EMBL
A team of scientists led by the Bork group at the European Molecular Biology Laboratory Heidelberg, along with their collaborators in the Netherlands and Australia, has now used this unusual medical procedure to ask a fascinating question – what happens when two gut microbiomes mix together? A machine-learning approach was developed by the team to dissect the factors that determine microbial dynamics after an FMT, including the presence or absence of individual microbial species. Their findings show that species richness , as well as how different a recipient’s gut microbiome is from a donor’s, are both major factors in determining which species will survive and thrive after a transplant.
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