A recent statement provides guidance on managing cardiovascular-kidney-metabolic syndrome, bringing us back to the roots of treating metabolic syndrome, writes Naresh Kanumilli, MBBS.
Consultant, Department of Diabetes, Manchester University Foundation Trust, Manchester, United Kingdom
No disease state — especially diabetes — exists in isolation, and we already know that as we get older, we generally tend to have more coexisting conditions which have a bearing on the 3 Ms : management, morbidity, and mortality. The American Heart Association statement acknowledges critical gaps in knowledge related to the mechanisms of disease development, heterogeneity related to phenotype, and the role of SDOH.
The statement also points out the dearth of evidence on early detection and prevention and reducing the risk associated with SDOH, especially those attributed to poverty, ethnicity, and deprivation. it elucidates clearly the interconnectedness and the mechanistics associated with SDOH, which include hyperglycemia and hemodynamic, metabolic, inflammatory, and fibrotic processes.
In the statement, the AHA authors acknowledge important gaps in our knowledge and research, especially with regard to mechanisms of cardiovascular disease development in CKM, heterogeneity within CKM, the need for longitudinal studies, and understanding of the bidirectional cardiovascular-kidney relationships.
Cardiovascular Risk CV Risk Factors Cardiovascular Risk Factors Cardiovascular Risk Management Cardiometabolic Risk Cardiometabolic Risk Factors Metabolism Metabolic Social Determinants Of Health SDOH Social Determinants Of Health (SDOH) Metabolic Syndrome Kidneys Fellowship Fellows Residency Residents Hypertension Heart Primary Care Cardiovascular Disease
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