The Cardiff flanker suffered a serious knee injury during Wales' 2018 Autumn win over the Springboks and was sidelined from all rugby for more than two years.
But he now returns to Test duty among six changes following Wales' 54-16 defeat by New Zealand in their Autumn Nations Series opener in Cardiff last weekend.
Experienced centre Jonathan Davies will lead Wales in Jones' absence, with wing Louis Rees-Zammit and fly-half Dan Biggar -- who both missed the New Zealand match after their England-based clubs refused to release them for a Test outside World Rugby's designated window -- returning to the back division.
"I don't think he will be available for the Six Nations," Pivac, whose side begin the Championship against Ireland in Dublin on February 5, told a press conference. Wales have won their last four Tests at home to South Africa, with the Springboks' last victory in Cardiff coming in 2013.
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