Vitamin D supplementation reduces risk of major cardiovascular events in older adults VitaminD Research Cardiovascular Health Supplementation HeartHealth OlderAdults HeartDisease Cardiology bmj_latest
By Dr. Priyom Bose, Ph.D.Jul 4 2023Reviewed by Benedette Cuffari, M.Sc. Stroke and coronary heart disease are the two most common causes of global death, with aging increasing the risk of both these events. Previous studies have indicated that vitamin D influences cardiovascular disease.
Background Within the vascular system, most of the cells that express the vitamin D receptor also express 1α-hydroxylase and can convert 25-hydroxyvitamin D D) to calcitriol, the active form of vitamin D. Calcitriol has several important biological functions including inflammation reduction, inhibition of proliferation of vascular smooth muscle, and regulation of the renin-angiotensin-aldosterone system.
About the study The current study used data from the D-Health Trial to investigate whether vitamin D supplementation in Australian adults over the age of 60 years influenced the incidence of major cardiovascular events. Computer-generated permuted block randomization was used to assign participants in a 1:1 ratio in two groups randomly. One group received 60,000 IU of vitamin D3 , while the others received placebo tablets. Both vitamin D3 and placebo tablets were identical in appearance.
Study findings A total of 21,315 participants were eligible for the D-Health Trial. Some participants left the trial for personal reasons, whereas others were removed for incomplete data. During the follow-up period,1,336 major cardiovascular events were noted, including 6% and 6.6% of the vitamin D and placebo groups, respectively. This finding indicates a lower incidence of cardiovascular events, particularly myocardial infarction, and coronary revascularization, in the vitamin D group compared to the placebo group.
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