Utilizing CRISPR to discover new therapy options for COPD

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Utilizing CRISPR to discover new therapy options for COPD
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Continuing our coverage of SLAS_org 2023, we speak to Ceri Wiggins, the Director of Functional genomics at AstraZeneca, about the many applications of CRISPR and its role in discovering new COPD therapies. Read more below!🧬👇

Sponsored Content by Society for Laboratory Automation and Screening Feb 20 2023 Thought LeadersCeri WigginsDirector, Functional GenomicsAstraZeneca Continuing our coverage of SLAS 2023, we speak to Ceri Wiggins, the Director of Functional Genomics at AstraZeneca, about the many applications of CRISPR and its role in discovering new COPD therapies.

The group has grown significantly in the past year, and the operational leadership of the 20+ scientists and students in the team accounts for a significant proportion of my time. As part of the Functional Genomics leadership team, my colleagues and I are responsible for setting a clear scientific strategy for the department and ensuring we can deliver it. My role is incredibly diverse, the pace is fast, and no two days are alike – which is probably why I enjoy it so much.

We aim to build a target validation package around strong hits and work with our therapy area colleagues to validate findings in multiple donors or even patient material. The governance structure surrounding new targets always includes an assessment of the target safety profile and the commercial environment, and the hope would be that targets discovered by our screens would enter the Respiratory & Immunology portfolio.

How important are scientific conferences such as SLAS in fostering new partnerships and challenging new research ideas? For me, conferences are a brilliant way for scientists to connect and expand their knowledge and network. As a scientific community, we felt this loss during the COVID pandemic, and while virtual events helped bridge the gap, they also highlighted the importance of face-to-face events.

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