New data highlight the innovative direction of microbiome modulation strategies in the field of cancer therapy. Read the News and Views from JenWargoMD and colleagues MDAndersonNews
, but a substantial proportion of patients do not derive durable benefit.
Thus, there is a crucial need to better understand the multitude of host-intrinsic and -extrinsic factors that shape response and resistance to cancer treatment and, crucially, those that can be modulated to enhance response. The microbiome is one such factor that can have a profound effect on carcinogenesis, cancer progression and therapy response. As such, strategies to target the microbiome are increasingly being explored in the treatment of cancer and other diseases.
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