Aging is a major risk factor for neurodegenerative diseases, but the molecular mechanisms behind this relationship are not clear. In a recent study, researchers explored the role of PQBP3, a protein that helps stabilize the nuclear membrane, in cellular senescence and neurodegeneration.
Their findings suggest that PQBP3 might be a promising therapeutic target for managing neurodegenerative diseases and the neuronal symptoms of aging.
To shed light on the role of this protein, the researchers employed cellular senescence as a model to study aging. Senescence refers to a state in which a cell no longer undergoes division, but remains alive and metabolically active. This state, which can be replicated in cell cultures, occurs naturally in our bodies and is typically observed in aging cells.
To shed light on this destabilization of the nuclear membrane, the researchers conducted a bioinformatics analysis using protein interaction databases. The results suggested that PQBP3 binds to a protein called proteasome activator complex subunit 3 or PSME3, which plays a key role in the degradation of other proteins.
"Since PQBP3 function loss can occur in both cellular senescence and neurodegeneration in brain neurons. Therefore, targeting PQBP3 theoretically makes it possible to improve both brain aging and neurodegeneration."
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