Researchers demonstrated that the crosstalk between IL1RL1+ regulatory T-cells (Treg) and cancer-associated fibroblasts (CAFs) drives the tissue repairing.
By Neha MathurAug 30 2023Reviewed by Lily Ramsey, LLM In a recent article published in the Science Advances Journal, researchers demonstrated that the crosstalk between IL1RL1+ regulatory T-cells and cancer-associated fibroblasts drives the tissue repairing and immunosuppressive CAF functional state, which is crucial for promoting tumorigenesis and maintaining cancer immune tolerance.
In case of tissue damage due to an environmental insult, tumor growth, or other diseases , IL-33 alerts several target immune cells expressing IL1RL1 , which initiates a cascade of immunological and pathological processes. AREG activates EGFR to promote the expression of tumor-growth factor-beta in CAFs, which likely causes immunosuppression in the TME. Notably, EGFR expression is predominant in CAFs but not Treg cells and other cell types in the TME. However, the precise mechanisms used by IL1RL1+ Treg cells to alter the TME and promote tumorigenesis are still elusive.
They performed paired single-cell ribonucleic acid sequencing and T-cell receptor sequencing of TCR-β+ T cells to analyze the immune cellular network in B16 and B16–IL-33 tumors on day nine post-tumor inoculation. Results The study data comprised 11,022 cells of three T-cell lineages: conventional T cells, cluster of differentiation 4+ Treg cells, and CD8+ T cells. B16–IL-33 versus B16 tumors showed increased Treg and CD8+ T cells and decreased Tconv cells accumulation.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Unlocking ACE2: The enzyme that links COVID-19, heart disease, and diabetesA recent study in the Journal of Biomedical Science examines the critical role of ACE2, an enzyme involved in blood volume and electrolyte balance, in chronic diseases like cardiovascular conditions, diabetes, and COVID-19. The research suggests that ACE2 could serve as both a disease severity biomarker and a therapeutic target.
Read more »
Rumble in the genome: Unlocking the secrets of the tiny RNAs that keep self-serving, harmful genes in checkDevelopmental biologist Eric Lai, Ph.D., and his lab at Memorial Sloan Kettering Cancer Center (MSK) have been studying hotbeds of biological conflict, except instead of battles between outside invaders and internal defenders, they've uncovered an evolutionary battle of the sexes fought using a group of recently emerged genes. This conflict between the X and Y chromosomes plays out in a hidden struggle between 'selfish' genetic actors and the small strands of RNA that keep them in check.
Read more »
Researchers find key for transforming cancer cells to muscle in rhabdomyosarcomaFor six years, Professor Christopher Vakoc's lab at Cold Spring Harbor Laboratory has been on a mission to transform sarcoma cells into regularly functioning tissue cells. Sarcomas are cancers that form in connective tissues such as muscle. Treatment often involves chemotherapy, surgery, and radiation—procedures that are especially tough on kids. If doctors could transform cancer cells into healthy cells, it would offer patients a whole new treatment option—one that could spare them and their families a great deal of pain and suffering.
Read more »
Exploring the role of hypoxia-inducible factors in vascular smooth muscle cells under panvascular pathologiesAs an emerging concept, panvascular diseases encompass a group of cardiovascular disorders characterized mainly by atherosclerosis, involving crucial organs such as the heart, brain, kidneys, and limbs. Hypoxia-inducible factor (HIF) plays a pivotal role as a major regulatory factor in the cardiovascular system's response to common stressors, such as hypoxia.
Read more »
Turncoat T cells underlie assault on small intestine amid gluten-induced chaos of celiac diseaseWheat, barley and rye contain a protein that can produce severe intestinal symptoms in people with celiac disease, and a team of scientists at Columbia University in New York has now identified distinct signatures of immune system cells that drive the disorder.
Read more »
FactCheck: government spends millions on overspill prison cells in police stations, exclusive data revealsSome police forces told us they received six figure sums for providing cells that weren’t ever occupied.
Read more »