Science, Space and Technology News 2024
Duke University researchers have developed a new flu vaccine targeting the more stable stalk region of the hemagglutinin protein, showing promise in mice and ferrets for providing broader, longer-lasting protection against influenza. This approach could diminish the need for annual flu vaccinations and improve global health outcomes.
Flu shots — and immune systems — tend to target the bulb-like “head” of hemagglutinin rather than the stalk. But the details of that head region also change constantly, creating an arms race between vaccine design and viruses. The stalk, by comparison, changes much less. Using gene editing, they created more than 80,000 variations of the hemagglutinin protein with changes in one portion right on the top of the head domain and then tested a vaccine filled with a mixture of these variations on mice and ferrets.
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