The term 'undruggable' refers to proteins or targets that are challenging to target with conventional drugs.
Targeted therapeuticsFurther reading
One prominent example of a druggable cancer target is the epidermal growth receptor , which has been successfully targeted in several cancers, including certain types of lung and breast cancers.Targeted therapeutics Targeted therapies have brought about a significant transformation in cancer treatment strategies. Unlike traditional chemotherapy, which harms both cancer and healthy cells alike, targeted therapies are specially designed to interact with the unique characteristics of cancer cells.
However, challenges persist, such as immune resistance and the need to identify suitable biomarkers for selecting the most appropriate treatments for individual patients. These proteins are hard to target with drugs because they are located inside the cells, often in the nucleus, and they work together with many other molecules to control gene activity.
Addressing these challenges Continued technological advancements have expanded our understanding of the molecular complexities of cancer cells and provided innovative tools for drug discovery. One prominent technological advancement is the use of fragment-based drug discovery .
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