Understanding the developmental link: vitamin D's role in metabolic disease risk NatureComms UWMedicine vitamind VD vitaminddeficiency deficiency diabetes type2diabetes T2D metabolicdisease
By Tarun Sai LomteJun 14 2023Reviewed by Lily Ramsey, LLM A recent study in the Nature Communications Journal showed that transplanting fetal hematopoietic stem cells exposed to in-utero vitamin D deficiency into VD-sufficient mice can induce diabetes.
Studies show that in utero, VD deficiency in mice can cause systemic inflammation, excess adiposity, IR, and hepatic steatosis in the offspring, despite VD supplementation post-birth. Related StoriesEight weeks post-transplant, hyperinsulinemic-euglycemic clamping of primary recipients revealed peripheral IR induction and perigonadal fat as the primary insulin-resistant tissue. This epididymal white adipose tissue showed immune cell proliferation or infiltration that was more than 99% donor-derived and predominated by pro-inflammatory M1 macrophages.
Increased miR-106b-5p secretion was also observed in secondary transplant recipients. Transfecting mouse adipocytes with mimics of the most abundant miRNAs identified in ATMs revealed a significant induction of adipocyte IR by miR-106b-5p and Let-7g-5p.
South Africa Latest News, South Africa Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Flight turbulence increasing as planet heats up - studyResearchers found that severe turbulence had increased 55% between 1979 and 2020 on a typically busy North Atlantic route.
Read more »
Obesity impairs the brain's response to nutrients, suggests studyBrain responses to specific nutrients are diminished in individuals with obesity and are not improved after weight loss, according to a study led by Amsterdam UMC and Yale University, published today in Nature Metabolism.
Read more »
Driver disguises himself as car seat for study👻🚗 A 'ghost driver' was used as part of a study to learn how pedestrians react to driverless cars. Read more:
Read more »
Gut microbiome transitions across generations in different ethnicities in an urban setting—the HELIUS study - MicrobiomeBackground During the course of history, various important lifestyle changes have caused profound transitions of the gut microbiome. These include the introduction of agriculture and animal husbandry, a shift from a nomadic to a more sedentary lifestyle, and recently increased levels of urbanization and a transition towards a more Western lifestyle. The latter is linked with shifts in the gut microbiome that have a reduced fermentative capability and which are commonly associated with diseases of affluence. In this study, in which 5193 subjects are included, we investigated the direction of microbiome shifts that occur in various ethnicities living in Amsterdam by comparing 1st and 2nd generation participants. We furthermore validated part of these findings with a cohort of subjects that moved from rural Thailand to the USA. Results The abundance of the Prevotella cluster, which includes P. copri and the P. stercorea trophic network, diminished in the 2nd generation Moroccans and Turks but also in younger Dutch, whilst the Western-associated Bacteroides/Blautia/Bifidobacterium (BBB) cluster, which has an inverse correlation with α-diversity, increased. At the same time, the Christensenellaceae/Methanobrevibacter/Oscillibacter trophic network, which is positively associated with α-diversity and a healthy BMI, decreased in younger Turks and Dutch. Large compositional shifts were not observed in South-Asian and African Surinamese, in whom the BBB cluster is already dominant in the 1st generation, but ASV-level shifts towards certain species, associated amongst others with obesity, were observed. Conclusion The Moroccan and Turkish populations, but also the Dutch population are transitioning towards a less complex and fermentative less capable configuration of the gut microbiota, which includes a higher abundance of the Western-associated BBB cluster. The Surinamese, whom have the highest prevalence of diabetes and other diseases of affluence, are already dominated by t
Read more »
Study reveals alarming pediatric antibiotic prescribing practices in Madagascar, Senegal, and CambodiaIn a recent article published in the journal PLOS Medicine, researchers performed a prospective, longitudinal study to estimate the proportion of outpatient consultations resulting in inappropriate antibiotic prescriptions in young children in three low- and middle-income countries (LMICs), Madagascar, Senegal, and Cambodia.
Read more »
Derby school chosen to take part in LGBT+ studyLees Brook Academy took part in the All Inc project to promote inclusive education.
Read more »