People over 70 have a heightened risk of cancer, but are under-represented in clinical trials of new drugs. That can be dangerous. (via undarkmag)
, not much has changed in the past three decades. “We’re in this space where everyone agrees this is a problem, but there’s very little guidance on how to do better for older adults,” Kvale said. “The consequences in the real world are stark.”of cancer drugs have helped shed light on the disconnect between how these drugs are used in clinical trials and how they are used in clinics around the country.
People over the age of 65 don’t fare well with other types of cancer treatments either. About half of older patients with advanced cancer experienceside effects with chemotherapy, which can lead oncologists to lower medication doses, as in Yeldell’s case. Since the earliest reports of this data gap, regulators and researchers have tried to fix the problem. Changes to clinical trials have, in principle, made it easier for older adults to sign up. For instance, most studies no longer have an upper age limit for participants.
As a group, older adults do experience more side effects, sometimes so severe that the cure rivals the disease. In the absence of evidence from clinical trials, clinicians and patients have tried to find other ways to predict how a patient’s age might influence their response to treatment. In Yeldell’s case, discussions with Kvale and his care team led him to choose a less intensive course of treatment that has kept his cancer stable since October 2022.
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