The drug, donanemab, has been shown to slow progression of memory and thinking problems by about a third. Read more at straitstimes.com.
NEW YORK - Treating Alzheimer’s patients as early as possible – when symptoms and brain pathology are mildest – provides a better chance of slowing cognitive decline, a large study of an experimental Alzheimer’s drug presented Monday suggests.can modestly slow the progression of memory and thinking problems in early stages of Alzheimer’s, and that the slowing was greatest for early-stage patients when they had less of a protein that creates tangles in the brain.
“No matter how you cut the data – earlier, younger, milder, less pathology – every time, it just looks like early diagnosis and early intervention are the key to managing this disease,” he added. The donanemab trial had higher rates of swelling and bleeding than the Leqembi trial, but comparisons are difficult because of differences in patients and other factors.
But Eisai, the Japanese company that makes Leqembi along with the company Biogen, based in Boston, has said it is unclear if the drug contributed to those deaths because those patients had complex medical issues. Donanemab and Leqembi, infusions that are administered intravenously, are the first amyloid-attacking drugs with clear evidence of slowing cognitive decline early in the disease.
On the same scale in the donanemab trial, the overall group of patients receiving the drug, delivered in monthly infusions, declined 29 per cent more slowly than the placebo group – or a difference of seven-tenths of a point. The difficulty of predicting if these drugs will be meaningful in daily life is reflected in the experience of a patient in another donanemab trial.
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