In the randomized trial QUEST trial, a traditional Chinese medicine called qiliqiangxin provided significant reductions in CV death and hospitalization on top of guideline-directed therapy in HFrEF.
In the newly completed multicenter trial, called QUEST, the goal was to determine whether this therapy could reduce hard endpoints relative to placebo in a rigorously conducted trial enrolling patients receiving an optimized triple-therapy heart failure regimen.
In this trial, 3119 patients were randomly assigned at 133 centers in China to take four capsules of qiliqiangxin or placebo three times per day. At a median follow-up of 18.3 months, outcomes were evaluable in nearly all 1561 patients randomly assigned to the experimental therapy and 1555 patients randomly assigned to placebo.
At enrollment, more than 80% of patients in both arms were receiving a renin-angiotensin system inhibitor , more than 80% were receiving a mineralocorticoid receptor antagonist, and more than 85% were receiving a β-blocker.By hazard ratio , the primary composite endpoint of CV death and heart failure hospitalization was reduced by 22% relative to placebo .
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