There's a Major Issue With How We Treat Lab Mice, And It Could Affect Study Results

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There's a Major Issue With How We Treat Lab Mice, And It Could Affect Study Results
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Over 120 million laboratory rats and mice are used worldwide each year. Many are used to study distressing conditions like cancer, arthritis and chronic pain, and nearly all spend their lives in small, empty box-like cages: a kind of permanent lockdo

. This raises worrying questions about their welfare – and about how well they represent typical human patients.

We identified this impact of housing by extracting data from over 200 studies that investigated the effects of cage design on health outcomes known to be stress-sensitive in humans, such as mortality rates and the severity of illnesses like cardiovascular disease, cancer and stroke.

Across the board, the animals in conventional cages became sicker than ones in better-resourced housing. For example, if given cancer, they developed larger tumors. Conventionally housed animals were also at greater risk of dying, their average lifespans reduced by about 9 percent. Scientists have known for decades that rats and mice want, and that conventional cages therefore induce abnormal behavior and anxiety.

But this is the first evidence that they also cause chronic distress severe enough to compromise animals' health.

We have summarized this news so that you can read it quickly. If you are interested in the news, you can read the full text here. Read more:

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