Anti-obesity medication (AOM) can be an invaluable tool for individuals who are unable to sustain long-term weight loss through lifestyle changes alone. Recent groundbreaking findings from a phase 2 trial have shown immense potential for a new AOM.
have shown glucagon to be an important regulator of proprotein convertase subtilisin/kexin type 9degradation, with the lack of glucagon resulting in increased PCSK9 levels, decreased LDL receptors, and increased plasma LDL; conversely, treatment with glucagon decreased plasma LDL., retatrutide was observed to have a side effect profile largely similar to other NuSH therapies , with a predominance of gastrointestinal symptoms including nausea, diarrhea, vomiting, and constipation.
Cutaneous hyperesthesia and skin sensitivity were reported inin the retatrutide group vs 1% in the placebo group; none of these effects were associated with physical skin findings. Of note, 17 out of 198 participants in the retatrutide group developed cardiac arrhythmia vs two out of 70 in the placebo group. There was no consistent pattern of arrhythmia type observed, and some of these events were reported as"palpitations" or"increased heart rate" without further detail.
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