In the nearly 120 years since Alzheimer’s disease was first identified, no one has figured out how to slow its progression, let alone prevent it or reverse its damage—but a new clinical trial may indicate a breakthrough.
Later, an eighteen-month congressional investigation found irregularities in the relationship between Biogen and the F.D.A. that enabled the company to get the drug approved despite limited evidence of its efficacy. Internal documents obtained by the lawmakers also showed that Biogen priced the treatment so exorbitantly because it wanted aducanumab to be “one of the top pharmaceutical launches of all time.
Those different targets may explain why Eisai’s trial was more successful than Biogen’s, but other factors were at work, too. Eisai’s trial only enrolled participants in the earliest stages of the disease. They all also had to have evidence of amyloid plaques in their brains.
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