A Review published in the Journal of Biomedical Science presents the potential and actual impact of CRISPR-Cas research on human tuberculosis understanding and management.
]. Future prospective cohort studies will certainly shed light on the clinical relevance of the low abundance-cfDNA. Considering that respiratory samples in children are difficult to obtain, this blood-based method has an additional advantage. In addition, unlike what is observed with NAATs based on respiratory specimens, cfDNA levels declined after anti-tuberculous treatment, endorsing its potential use for treatment monitoring.
Massive application of CRISPR technology for diagnosis must overcome several challenges in the future which are summarized in Box. First, the tests developed so far rely on DNA extraction methods which require laboratory equipment that is not available in resource-constrained settings or at the POC. Next, molecular diagnosis methods for tuberculosis have the additional challenge of high cross-contamination rates and biosafety requirements for culture-based methods.
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