A team led by Professor Choi Hong-Soo in the Department of Robotics and Mechatronics Engineering at DGIST has discovered a method to enhance the penetration of magnetic nanoparticles into cancer cells and their magnetic hyperthermia effects through research on chain disassembly and magnetic propulsion mechanisms using a rotational magnetic field.
, their study focused on the delivery of magnetic therapeutic agents using magnetic fields, an area receiving attention in the field of cancer treatment. It is expected to contribute significantly by improving drug delivery efficiency and therapeutic effects in targeted cancer treatments.has been gaining attention in the field of cancer treatment. Among them, research on magnetic carriers that target cancer cells using magnetic fields is underway.
In response, the team led by Professor Choi Hong-Soo at DGIST analyzed the interaction between the behavior of magnetic nanoparticles and fluidic viscosity resistance using a unique rotational magnetic field, conducting research on chain disassembly mechanisms that can selectively control magnetic nanoparticle chain lengths.
First, the team verified the chain disassembly mechanism of magnetic nanoparticles induced by a rotational magnetic field. Targeting cancer cells and tumor spheroids, they induced increased cellular absorption and penetration by driving magnetic nanoparticles with a rotational magnetic field.
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