Patients taking sulthiame, a drug currently in use for epilepsy, experienced a reduction in their symptoms of obstructive sleep apnoea (OSA), according to results of a clinical trial presented at the European Respiratory Society (ERS) Congress in Vienna, Austria.
European Respiratory SocietySep 10 2024 Patients taking sulthiame, a drug currently in use for epilepsy, experienced a reduction in their symptoms of obstructive sleep apnoea , according to results of a clinical trial presented at the European Respiratory Society Congress in Vienna, Austria.
The trial was a double-blind, randomized, placebo-controlled trial – the gold-standard in medical research. It involved 298 people with OSA being treated at 28 different centers in Spain, France, Belgium, Germany and the Czech Republic. All the patients could not tolerate or refused to use continuous positive airway pressure machines or mouthpieces designed to keep the airways open.
The people taking sulthiame had fewer pauses in their breathing and higher levels of oxygen in their blood during sleep. A measure of the frequency of respiratory pauses during sleep, called AHI3a , was 17.8% lower for patients taking the lowest dose, 34.8% lower for patients on the medium dose and 39.9% lower for patients on the highest dose.
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