Study using circulating spike protein and macrophage dysregulation liquid biomarkers reveals heterogeneity in PASC medrxivpreprint UniHalle SARSCoV2 COVID19 PASC
By Dr. Chinta SidharthanSep 22 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers designed a liquid biomarker panel consisting of macrophage and monocyte-related soluble factors and circulating spike proteins to understand profiles of immune dysregulation in patients with post-acute sequelae of coronavirus disease 2019 .
However, an understanding of the underlying mechanisms of PASC, such as innate and adaptive immune dysregulation, is lacking. Results The results reported strong dysregulation of macrophage- and monocyte-related soluble factors such as chemokines and pro-fibrotic and pro-inflammatory cytokines in individuals with PASC. The authors observed that, with a few exceptions, these factors display a correlation pattern independent of the ongoing symptoms of PASC.
The study also identified two correlation patterns specific to PASC that involved MCP-1/CCL2, a range of interleukins, type I interferons, and soluble CD162 and CD206. These correlations suggest transitions from pro-inflammatory TH1 responses during acute COVID-19 to TH2 responses, which result in macrophage-related lung fibrosis in PASC.
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