Study shows vaccine-derived poliovirus in infant with severe immunodeficiency CDCgov Poliovirus Infant Immunodeficiency
By Tarun Sai LomteSep 13 2022Reviewed by Aimee Molineux In a recent study published in Morbidity and Mortality Weekly Report, researchers identified type 3 vaccine-derived poliovirus in an infant.
Immunodeficiency-associated VDPV , integrated AFT, and environmental surveillance are pivotal to achieving the global eradication of polio. The first case of iVDPV was detected in the United Kingdom in 1962, and 149 iVDPV cases have been reported globally until May 2020. Most iVDPV patients develop paralysis before being diagnosed with immune deficiency and are mainly identified via AFP surveillance.
Initially, the patient was hospitalized at six months of life due to persistent diarrhea, diffuse red papules, fevers, and lymphadenitis. The subject was diagnosed with severe combined immunodeficiency due to heterozygous mutations in the zeta chain of T cell receptor-associated protein kinase 70 gene.
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