In mice, cognitive decline is influenced by obesity due to the potential association of an adipose-brain axis. To examine this proposal, Núria Olivera-Canellas, and a team of researchers in the departments of medicine and diabetes at the University of Girona, Spain, identified 188 genes by using RNA sequencing of adipose tissue in three patient cohorts associated with cognitive performance. The genes had associations with synaptic function, anti-inflammatory signaling, vitamin metabolism, phosphatidylinositol metabolism and the complement cascade.
associated with inhibitory control, working memory, immediate memory and attention. They also noted an overrepresentation of pathways associated with inflammation-linked cognitive domains, as well as altered notch signaling and complement activation associations with working memory.
associated with attention, while the complement system activated in visceral adipose tissue to indicate a strong association with performance in several cognitive domains. The subcutaneous adipose tissue pathways were associated with synaptic transmission, neuronal system, and one-carbon metabolism relative to long-term and short-term memory.
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