Study reviews hydroxychloroquine and remdesivir antiviral potency against SARS‐CoV‐2 nit_manipur ElsevierConnect SARSCoV2 COVID19 AntiviralPotency Remdesivir Hydroxychloroquine
By Neha MathurOct 17 2022Reviewed by Aimee Molineux In a recent study published in the Journal of Heterocyclic Chemistry, researchers outlined the synthesis and the possible mechanism of action of two potential severe acute respiratory syndrome coronavirus 2 repurposing drug candidates.
Background It is of urgent concern to contain SARS-CoV-2 and prevent coronavirus disease 2019 -related deaths. Based on the current and previously published evidence, the scientists believe that remdesivir and HCQ have adequate efficacy in combating COVID-19. Moreover, the optimal dosage of HCQ sulfate could produce serum levels of 1.4–1.5μM in humans. Besides containing SARS-CoV-2, HCQ sulfate is a benign and effective anti-inflammatory drug. It attains 200 to 700 times higher tissue deposition levels in the kidney, liver, lungs, and spleen compared to plasma. These serum concentrations could prevent SARS-CoV-2 infection in these tissues.
Related StoriesUnfortunately, studies have not yet clarified the MOA of CQ and HCQ entirely. However, studies have shown that these drugs first change the pH at the host cell membrane surface, which results in an inhibitory action on virus fusion to the cell membrane. Moreover, they interfere with viral replication by damaging nucleic acids.
The United States Food and Drug Administration has approved HCQ to treat COVID-19 in conditions where the clinical trials are unfeasible or for an unapproved symptom. However, FDA strongly recommends that patients inform their healthcare provider regarding medications for other health conditions.
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